ZYDUS LIFESCIENCES
ZYVAC TCV PFS
₹ 2,622 / Piece
No Charges till Medical Approval
Summary of Zyvac TCV (Typhoid Vi Conjugate Vaccine):
Zyvac TCV is a WHO-prequalified vaccine designed to protect against typhoid fever, caused by Salmonella Typhi bacteria. It is particularly recommended for individuals traveling to or living in typhoid-endemic regions. The vaccine contains the Vi capsular polysaccharide of Salmonella Typhi conjugated to a Tetanus Toxoid (TT) carrier protein, which enhances immune response.
How It Works:
Zyvac TCV contains inactivated components of Salmonella Typhi that stimulate the immune system to develop protection without causing illness. It elicits a T-cell-dependent immune response, unlike non-conjugated typhoid vaccines. Protection begins 2-3 weeks post-vaccination, though it is not 100% effective and does not protect against Salmonella Paratyphi or non-typhoid salmonella infections.
Administration:
Given as a single intramuscular injection in the deltoid (upper arm) for individuals over 2 years or the anterolateral thigh for children under 2 years.
Recommended for individuals aged 6 months to 65 years, especially those in or traveling to endemic areas.
Dosage:
Single dose; a booster can be given after 3 years for those at continued risk.
Side Effects:
Common side effects include pain/swelling at the injection site, mild fever, headache, and fatigue. Severe reactions are rare.
Pregnancy and Lactation:
Pregnancy: Not recommended; consult a healthcare provider to assess risks and benefits.
Lactation: Generally considered safe but consult a healthcare provider.
Minimum Age Group:
Approved for individuals aged 6 months to 65 years.
Contraindications:
Severe allergic reactions to any vaccine component.
Postpone vaccination in cases of acute, severe febrile illness.
Zyvac TCV is a crucial tool for typhoid prevention, particularly for travelers and residents in high-risk areas. Always consult a healthcare provider for personalized advice.
Prescription Compulsory
| Single Dose | Yes |
| 6mth-1yr age | Yes |
| 1-2 yr | Yes |
| Imported | No |
| Doses | 1 |
| Antigens | 1 |
| Vaccine Type | Inactivated |
| Pregnancy | No |
| Lactation | No |
| 6mth- 65 yr | Yes |
| Boosters | Yes, 3yrly |
| ACVIP 2020 Guidelines | Yes |
| Adult vaccine | Yes |
Zyvac TCV is a Typhoid Vi Conjugate vaccine used to protect against typhoid fever, caused by Salmonella Typhi bacteria. This vaccine is particularly important for individuals traveling to or living in areas where typhoid fever is common. The vaccine contains Vi capsular polysaccharide of Salmonella Conjugated to Tetanus Toxoid carrier protein. It is WHO and IP Prequalifies vaccine. Conjugated to TT protein antigen
How It Works
Zyvac TCV contains inactivated components of the Salmonella Typhi bacteria, which stimulate the immune system to develop protection against the disease without causing illness. It does not offer protection against infection caused by salmonella paratyphi or non typhoid salmonellas.Protection is not 100%. Protection starts in 2-3 weeks post vaccination.Serological Protection is T cell dependent. Plain Vi Polysaccharide (Non Conjugated Typhoid vaccines don’t elicit T cell response.
Administration
- Given as a single injection, usually in the upper arm(Deltoid, >2 yrs) or Anterolateral thigh (till 2 yrs)
- Recommended for individuals aged >6 months and older till 65 yrs, especially those traveling to endemic areas.
Doses
- Doses: Single dose. Booster after 3 yrs of Primary vaccination can be given to people who are at risk of typhoid fever
Side Effects
Common side effects may include:
- Pain or swelling at the injection site
- Mild fever
- Headache
- Fatigue
Severe reactions are rare.
Pregnancy and Lactation
- Pregnancy: Not to be given.Should be discussed with a healthcare provider to weigh risks and benefits.
- Lactation: Not to be given.Generally considered safe, but consult with a healthcare provider.
Minimum Age Group
- Minimum Age: Approved for use in individuals aged >6 months to 65 years.
Contraindications
- Allergic Reactions: Not for individuals with severe allergies to any component of the vaccine.
- Severe Illness: Vaccination should be postponed in cases of acute, severe febrile illness.
Zyvac TCV is essential for preventing typhoid fever, especially for travelers and those in endemic areas. Always consult healthcare providers for personalized advice and recommendations.
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