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Serum Institute

CERVAVAC

₹ 2,000 / Piece

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🛡️ CANCER PREVENTION VACCINE

Cervavac

Protection Against HPV-Related Cancers & Diseases

💉 4-Valent HPV Vaccine 🧬 Recombinant Technology 👫 For Ages 9-26 🏥 Cancer Prevention

Cervavac is a 4-valent recombinant HPV vaccine designed to protect boys and girls aged 9-26 years against Human Papillomavirus (HPV) strains 6, 11, 16, and 18. These HPV strains are responsible for causing cervical, vulvar, vaginal, anal, oropharyngeal, and other head and neck cancers, as well as genital warts and precancerous lesions. Cervavac offers comprehensive protection against some of the most common and dangerous HPV-related diseases.

🧬 4 HPV Strains - Complete Coverage

HPV 6
Low-Risk Type
Causes ~90% of genital warts
HPV 11
Low-Risk Type
Causes ~90% of genital warts
HPV 16
High-Risk Type
Causes ~70% of cervical cancers
HPV 18
High-Risk Type
Causes ~70% of cervical cancers

🛡️ What Diseases Does Cervavac Prevent?

Comprehensive Cancer & Disease Prevention

Cervavac protects against multiple HPV-related cancers and diseases:

🎗️

Cervical Cancer

HPV 16 & 18 cause ~70% of all cervical cancers

🎗️

Vulvar Cancer

Protection against vulvar cancers caused by HPV

🎗️

Vaginal Cancer

Prevention of vaginal cancers linked to HPV

🎗️

Anal Cancer

Protects both males and females from anal cancer

🎗️

Oropharyngeal Cancer

Prevents throat and mouth cancers caused by HPV

🎗️

Head & Neck Cancers

Protection against HPV-related head and neck cancers

⚠️

Genital Warts

HPV 6 & 11 cause ~90% of genital warts

⚠️

Precancerous Lesions

Prevents abnormal cell changes that can lead to cancer

👥 Who Should Get Cervavac?

✓ Recommended for Both Boys & Girls

  • Age range: 9 to 26 years
  • Girls & women: Protection against cervical, vulvar, vaginal, anal, and oropharyngeal cancers
  • Boys & men: Protection against anal, oropharyngeal, and head & neck cancers
  • Best age for vaccination: 11-12 years (before sexual activity begins)
  • Catch-up vaccination: Available for those who missed vaccination at younger ages (up to 26 years)

Why Vaccinate Before Sexual Activity?

HPV vaccination is most effective when given before exposure to the virus. Since HPV is transmitted through sexual contact, vaccinating before sexual activity begins provides maximum protection. However, even those who are already sexually active can benefit from the vaccine.

💉 Dosing Schedule by Age

Ages 9-14 Years

2-Dose Schedule

  • Dose 1: Initial dose
  • Dose 2: 6-12 months after first dose
  • Why 2 doses? Younger immune systems respond robustly with just 2 doses
  • Note: If second dose is given before 5 months, a third dose is needed
Ages 15-26 Years

3-Dose Schedule

  • Dose 1: Initial dose
  • Dose 2: 1-2 months after first dose
  • Dose 3: 6 months after first dose
  • Why 3 doses? Older individuals need additional dose for optimal immunity

🏥 Administration Details

How Cervavac is Given

  • Route: Intramuscular (IM) injection
  • Injection site for children & adults: Deltoid muscle (upper arm)
  • Alternative site for younger children: Anterolateral thigh
  • Dose volume: 0.5 mL per dose
  • Storage: Refrigerated at 2-8°C; do not freeze

💊 Side Effects

✓ Safe & Well-Tolerated

Cervavac has an excellent safety profile with millions of doses administered worldwide. Most side effects are mild and temporary.

Common Side Effects (Mild & Temporary)

  • Injection site reactions: Pain, redness, or swelling at the injection site (most common)
  • Headache: Mild to moderate headache
  • Fatigue: Temporary tiredness
  • Mild fever: Low-grade temperature elevation
  • Dizziness: Brief lightheadedness (usually resolves quickly)
  • Nausea: Mild stomach discomfort

Note: These side effects typically resolve within 1-2 days. Fainting can occur after vaccination (especially in adolescents), so it's recommended to sit for 15 minutes after injection. Severe allergic reactions are extremely rare.

⚠️ IMPORTANT: Vaccination Does NOT Replace Screening

  • Continue regular screenings: Cervavac does not eliminate the need for routine cervical cancer screenings (Pap smears, HPV tests)
  • Not 100% protection: The vaccine protects against 4 HPV types, but there are other oncogenic HPV types
  • For women: Continue regular gynecological check-ups and Pap smears as recommended by your doctor
  • For men: Discuss anal cancer screening with your healthcare provider if at high risk
  • Comprehensive approach: Vaccination + screening = maximum protection

🤰 Pregnancy and Lactation

⚠️ Not Recommended During Pregnancy

  • Pregnancy: Cervavac is NOT recommended during pregnancy. If pregnancy occurs after starting the vaccine series, remaining doses should be postponed until after delivery.
  • Pregnancy testing: Not required before vaccination, but avoid vaccination if pregnant
  • Lactation: Can be given during breastfeeding - the vaccine is considered safe for nursing mothers
  • Planning pregnancy: Complete the vaccine series before conception if possible

⚠️ Special Considerations

Immunocompromised Individuals

Cervavac should be used with caution in immunocompromised individuals, including those with:

  • HIV/AIDS: Can receive vaccine but may have reduced immune response
  • Cancer treatment: Patients undergoing chemotherapy or radiation
  • Immunosuppressive medications: Those on steroids or other immune-suppressing drugs
  • Organ transplant recipients: May have reduced vaccine effectiveness
  • Recommendation: Consult with healthcare provider to determine best timing and approach

🚫 Contraindications


Delivery Options

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Prescription Compulsory

Painless (gentle)Yes
ImportedNo
Doses2-3
Antigens4
Vaccine TypeInactivated
LactationYes
Boosters1-2
ACVIP 2020 GuidelinesYes
>9yrs to 45 yrsTill 26 yrs only
Age Group9-26 yrs
Adult vaccineYes

🛡️ CANCER PREVENTION VACCINE

Cervavac

Advanced Protection Against HPV-Related Cancers & Diseases

💉 4-Valent Recombinant 🧬 L1 VLP Technology 👫 Ages 9-26 🏥 Cancer Prevention

Cervavac is a Human Papillomavirus 4-valent Vaccine (Recombinant) designed to protect against HPV-related cancers and diseases. This advanced vaccine provides comprehensive protection against HPV strains 6, 11, 16, and 18, which are responsible for the majority of cervical cancers, genital warts, and various other HPV-related cancers. Cervavac is indicated for both girls and women, and boys and men aged 9 through 26 years.

🔬 Advanced Recombinant Technology

Production Strain: Hansenula polymorpha

Cervavac is produced using recombinant DNA technology with Hansenula polymorpha yeast strain. This method creates virus-like particles (VLPs) that mimic the structure of HPV but cannot cause infection, ensuring both safety and effectiveness.

  • Recombinant production: Safe and consistent manufacturing process
  • Virus-like particles: Mimics natural HPV structure without infection risk
  • No live virus: Cannot cause HPV infection
  • Intramuscular suspension: Ready-to-use injectable formulation

🧬 4 HPV Strains - Comprehensive Coverage

HPV 6
Low-Risk Type
Causes ~90% of genital warts (condyloma acuminata)
HPV 11
Low-Risk Type
Causes ~90% of genital warts (condyloma acuminata)
HPV 16
High-Risk Oncogenic
Causes ~70% of cervical cancers and other HPV-related cancers
HPV 18
High-Risk Oncogenic
Causes ~70% of cervical cancers and other HPV-related cancers

🛡️ Comprehensive Disease Prevention

Cervavac Protects Against Multiple HPV-Related Cancers

Cervavac provides protection against a wide range of serious HPV-related diseases:

🎗️

Cervical Cancer

Protection against the most common HPV-related cancer in women

🎗️

Vulvar Cancer

Prevention of vulvar cancers caused by HPV 16 & 18

🎗️

Vaginal Cancer

Protection against vaginal cancers linked to HPV

🎗️

Anal Cancer

Protects both males and females from anal cancer

🎗️

Oropharyngeal Cancer

Prevents throat and tonsil cancers caused by HPV

🎗️

Head & Neck Cancers

Protection against various head and neck cancers

⚠️

Genital Warts

HPV 6 & 11 cause ~90% of genital warts (condyloma acuminata)

⚠️

Precancerous Lesions

Prevents dysplastic lesions that can progress to cancer

📋 Precancerous & Dysplastic Lesions Prevention

Cervavac Prevents Multiple Types of Precancerous Conditions

Early-stage abnormal cell changes that can progress to cancer if left untreated:

Cervical Lesions

  • CIN Grade 1: Cervical Intraepithelial Neoplasia Grade 1 (mild dysplasia)
  • CIN Grade 2/3: Moderate to severe dysplasia
  • AIS: Cervical Adenocarcinoma in Situ

Vulvar Lesions

  • VIN Grade 2: Vulvar Intraepithelial Neoplasia Grade 2 (moderate dysplasia)
  • VIN Grade 3: Severe dysplasia

Vaginal Lesions

  • VaIN Grade 2: Vaginal Intraepithelial Neoplasia Grade 2 (moderate dysplasia)
  • VaIN Grade 3: Severe dysplasia

Anal Lesions

  • AIN Grade 1: Anal Intraepithelial Neoplasia Grade 1 (mild)
  • AIN Grade 2: Moderate dysplasia
  • AIN Grade 3: Severe dysplasia

🔬 How Cervavac Works - L1 VLP Technology

Advanced Virus-Like Particle (VLP) Mechanism

  • HPV specificity: HPV only infects human beings, making targeted vaccination effective
  • L1 protein VLPs: Vaccine contains virus-like particles made from L1 capsid protein
  • Humoral immune response: Protection is mediated by antibodies produced against HPV VLPs
  • Neutralizing antibodies: Body produces antibodies that prevent HPV from infecting cells
  • Long-term immunity: Creates immunological memory for sustained protection
  • Exact mechanism unknown: While efficacy is established through humoral immunity, the complete protective mechanism is still being studied

Understanding Humoral Immunity

The efficacy of Cervavac against anogenital diseases related to vaccine HPV types is thought to be mediated by humoral immune responses (antibody production) induced by the vaccine. These antibodies circulate in the bloodstream and prevent HPV from establishing infection when exposure occurs.

👥 Who Should Get Cervavac?

✓ Approved for Both Males & Females

  • Girls & women: Ages 9 through 26 years
  • Boys & men: Ages 9 through 26 years
  • Best age for vaccination: 11-12 years (before sexual activity begins)
  • Catch-up vaccination: Available for those aged 13-26 who missed earlier vaccination
  • Most effective: When given before exposure to HPV through sexual contact

⚠️ Important Limitation

Cervavac has not been demonstrated to provide protection against disease from vaccine and non-vaccine HPV types to which a person has previously been exposed through sexual activity.


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