GARDASIL 4

Gardasil 4 is a vaccine designed to protect against four types of human papillomavirus (HPV), a common virus that can lead to cervical cancer, genital warts, and other cancers such as those of the vulva, vagina, anus, and oropharynx. HPV is one of the most prevalent sexually transmitted infections, and vaccination with Gardasil 4 provides significant protection against the strains most commonly associated with these conditions.

How It Works

Gardasil 4 is a recombinant vaccine that targets four specific types of HPV: types 6, 11, 16, and 18. Types 16 and 18 are responsible for approximately 70% of cervical cancer cases, while types 6 and 11 cause about 90% of genital warts. The vaccine contains virus-like particles (VLPs) that mimic the HPV virus but do not cause infection. These VLPs stimulate the immune system to produce antibodies, providing immunity against future HPV infections from these types.

Administration

• Dosage: Gardasil 4 is typically administered as a series of two/ three doses.
• Schedule:
  • The first dose is given at an elected date.
  • Given as a series of two or three injections over six months.
  • The second dose is given 1-2 months after the first dose.
  • The third dose is administered 6 months after the first dose.
  • Age Regimen Schedule:

9 through 14 years

2-dose 0, 6 to 12 months

3-dose 0, 2, 6 months

• 15 through 45 years

  3-dose 0, 2, 6 months

• If the second dose is administered earlier than 5 months after the first

dose, administer a third dose at least 4 months after the second dose.

• Administration Method: Given as an intramuscular injection, usually in the upper arm (deltoid muscle) or thigh.

Side Effects

Common side effects may include:

• Pain, redness, or swelling at the injection site
• Headache
• Dizziness or fainting (more common in adolescents)
• Mild fever
• Nausea

Severe reactions are rare.

Pregnancy and Lactation

• Pregnancy: Gardasil 4 is not recommended for use during pregnancy. Women who become pregnant after starting the vaccination series should complete it after childbirth.
• Lactation: Safe for breastfeeding mothers, though consultation with a healthcare provider is recommended.

Age Group

• Minimum Age: Approved for use in individuals starting at 9 years old.
• Upper Age Limit: Recommended for use up to 26 years old for females and males, though it may be administered to older individuals in certain circumstances.

Contraindications

• Allergic Reactions: Not recommended for individuals with severe allergies to any component of the vaccine or to a previous dose of Gardasil.
• Severe Illness: Vaccination should be postponed in cases of acute, severe febrile illness.

Nature of Antigen

• Nature of Antigen: Gardasil 4 contains virus-like particles (VLPs) derived from the L1 protein of HPV types 6, 11, 16, and 18.

Vaccine Type

• Type: Gardasil 4 is a quadrivalent recombinant vaccine, meaning it protects against four specific HPV types.

Origin and Manufacturer

• Origin: Gardasil 4 is an imported vaccine.
• Manufacturer: The vaccine is produced by Merck & Co., Inc., a global healthcare company.
• Introduction Year: Gardasil 4 was introduced in 2006.

Gardasil 4 is an important vaccine for preventing HPV-related diseases, including cervical cancer and genital warts. Developed and produced by Merck & Co., Gardasil 4 provides comprehensive protection against four major HPV types. It is recommended for both females and males, particularly before exposure to HPV, making it a critical part of preventive healthcare. Always consult healthcare providers for detailed vaccination schedules and personalized advice.